L 652469
Tussilagone
CAS: 104012-37-5
Molecular Formula: C23H34O5
L 652469 - Names and Identifiers
L 652469 - Physico-chemical Properties
| Molecular Formula | C23H34O5 |
| Molar Mass | 390.51 |
| Density | 1.07±0.1 g/cm3 (20 ºC 760 Torr) |
| Boling Point | 471.3±35.0 °C(Predicted) |
| Specific Rotation(α) | -40 (c, 1 in CHCl3) |
| Solubility | Soluble in chloroform and methanol, hardly soluble in water |
| Appearance | White powder or crystal |
| Storage Condition | 2-8℃ |
| MDL | MFCD01709134 |
| Physical and Chemical Properties | White crystalline powder, soluble in ether, chloroform, ethyl acetate, methanol, insoluble in water, derived from the flower buds of the farfara of the Tussilago of the Compositae family, Senrito Senecio kleinia Less root. |
| In vitro study | Tussilagone suppressed the expression of the inflammatory mediators, nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1), in lipopolysaccharide-stimulated RAW 264.7 cells and peritoneal macrophages. Tussilagone also reduced the activation of the mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) involved in the activation of various inflammatory mediators in activated macrophages. |
| In vivo study | Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration. |
L 652469 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
L 652469 - Reference
| Reference Show more | 1. Min Min Chen. Effects of different storage conditions on the content of methyl ketone in Colina campestris [J]. Agricultural science and technology and information 2020(2):45-46. 2. Yan Shuang, He Yuxin, Mao Zhengrui, etc. Study on quality standard of honey-Fried Winter Flowers [J]. Journal of Xihua University (Natural Science Edition), 2019, 038(003):68-72. 3. [IF = 2.527] loading Jin et al."Tussilagone inhibitors allationresponses in OVA-induced allationics GUI a pigs and IgE-stimulated RBL-2H3 cells." Fitoterapia. 2020 Jul;144:104496 |
L 652469 - Introduction
Orange nail winter ketone (Cinnamaldehyde) is a kind of organic compounds, molecular formula C9H8O, chemical structure is C6H5-CH = CH-CHO. It is one of the main components of quercetin and has a unique aroma and pungent taste.
Arectone can be used as a spice in food, beverage and oral care products. It is commonly used as a flavoring agent in the food industry to impart aroma and mouthfeel to meats, biscuits, candies, cakes, etc. In addition, arecone can also be used as soap, perfume and other cosmetics spices, with good health and beauty effects, such as promoting blood circulation and reducing skin scab itching.
The preparation method of arecone generally involves the reaction process, which can be obtained by The Reflux reaction of cinnamaldehyde and potassium acetate (or sodium formate). The preparation method can also be obtained by gas phase oxidation of cinnamyl alcohol under the catalysis of acetic anhydride, or by preparing cinnamaldehyde through intermolecular reaction, and then dealdehyde under alkaline conditions. The specific preparation method can be adjusted as needed.
Arectone has good safety under proper conditions of use. However, for sensitive people (such as people with allergies or people allergic to spices), it may cause allergic reactions when used, so use with caution. During use, avoid contact with skin and eyes, and pay attention to protective measures, such as wearing gloves and goggles. At the same time, keep away from fire and oxidant during storage and use to avoid the risk of fire and explosion. For children and pets, please keep it properly and avoid eating by mistake. Before use, it is best to understand the detailed description of the product and the relevant safety operation guide.
Arectone can be used as a spice in food, beverage and oral care products. It is commonly used as a flavoring agent in the food industry to impart aroma and mouthfeel to meats, biscuits, candies, cakes, etc. In addition, arecone can also be used as soap, perfume and other cosmetics spices, with good health and beauty effects, such as promoting blood circulation and reducing skin scab itching.
The preparation method of arecone generally involves the reaction process, which can be obtained by The Reflux reaction of cinnamaldehyde and potassium acetate (or sodium formate). The preparation method can also be obtained by gas phase oxidation of cinnamyl alcohol under the catalysis of acetic anhydride, or by preparing cinnamaldehyde through intermolecular reaction, and then dealdehyde under alkaline conditions. The specific preparation method can be adjusted as needed.
Arectone has good safety under proper conditions of use. However, for sensitive people (such as people with allergies or people allergic to spices), it may cause allergic reactions when used, so use with caution. During use, avoid contact with skin and eyes, and pay attention to protective measures, such as wearing gloves and goggles. At the same time, keep away from fire and oxidant during storage and use to avoid the risk of fire and explosion. For children and pets, please keep it properly and avoid eating by mistake. Before use, it is best to understand the detailed description of the product and the relevant safety operation guide.
Last Update：2024-04-09 21:31:56
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Spot supply
Product Name: Tussilagone Visit Supplier Webpage Request for quotationCAS: 104012-37-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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